Play: Denver -7 -110
Time: 4:40 p.m. ET
Reasoning: The Broncos are 8-0 this season at Mile High and they are outscoring opponents by 14.6 ppg. They are 22-2 in Denver over the last three years under Peyton Manning, who has a 117.5 QB rating at home this season. The Colts allowed 31 or more points in four road games this season. In Week 1 the Broncos led Indianapolis by as much as 24 points before the Colts mounted a comeback and covered the eight-point spread but lost straight up 31-24. Indianapolis played the NFL's seventh-easiest schedule. The Colts went 1-4 vs. Top 10 teams and 3-5 vs. Top 16 teams. Denver played the fourth-toughest schedule and was 4-2 vs. Top 10 teams and 8-2 vs. Top 16 teams. The Broncos have won five of their last six, with the only loss being a 37-28 defeat at Cincinnati on Dec. 22. During those six games Denver totaled 13 takeaways. The Broncos are second in the league in rush defense (79.8 rpg) and Indianapolis has allowed 126.2 ypg rushing over the last five games.
Record: 241-187-8 (56.3%)
Bankroll: +114.97%
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